MRF4 can substitute for myogenin during early stages of myogenesis
نویسندگان
چکیده
منابع مشابه
Myogenin is required for late but not early aspects of myogenesis during mouse development
Mice with a targeted mutation in the myogenic basic helix-loop-helix regulatory protein myogenin have severe muscle defects resulting in perinatal death. In this report, the effect of myogenin's absence on embryonic and fetal development is investigated. The initial events of somite differentiation occurred normally in the myogenin-mutant embryos. During primary myogenesis, muscle masses in mut...
متن کاملTHE DILEMMA OF HEMODYNAMIC INSTABILITY DURING INDUCTION OF ANESTHESIA: CAN MIDAZOLAM SERVE AS A SUITABLE SUBSTITUTE FOR THIOPENTONE?
Both midazolam and thiopental sodium are being used as induction agents and for maintenance of anesthesia. In contrast to other benzodiazepines such as diazepam, midazolam has a rapid onset of action and fast distribution and causes few cardiovascular or respiratory effects. Being water soluble, midazolam is also associated with a low incidence of venous irritation. The purpose of this stu...
متن کاملDifferential binding of quadruplex structures of muscle-specific genes regulatory sequences by MyoD, MRF4 and myogenin
Four myogenic regulatory factors (MRFs); MyoD, Myf-5, MRF4 and Myogenin direct muscle tissue differentiation. Heterodimers of MRFs with E-proteins activate muscle-specific gene expression by binding to E-box motifs d(CANNTG) in their promoters or enhancers. We showed previously that in contrast to the favored binding of E-box by MyoD-E47 heterodimers, homodimeric MyoD associated preferentially ...
متن کاملOverlapping functions of the myogenic bHLH genes MRF4 and MyoD revealed in double mutant mice.
The myogenic basic helix-loop-helix (bHLH) genes - MyoD, Myf5, myogenin and MRF4 - exhibit distinct, but overlapping expression patterns during development of the skeletal muscle lineage and loss-of-function mutations in these genes result in different effects on muscle development. MyoD and Myf5 have been shown to act early in the myogenic lineage to establish myoblast identity, whereas myogen...
متن کاملAdaptation of nicotinic acetylcholine receptor, myogenin, and MRF4 gene expression to long-term muscle denervation
Muscle activity alters the expression of functionally distinct nicotinic acetylcholine receptors (nAChR) via regulation of subunit gene expression. Denervation increases the expression of all subunit genes and promotes the expression of embryonic-type (alpha 2 beta delta gamma) nAChRs, while electrical stimulation of denervated muscle prevents this induction. We have discovered that the denerva...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Developmental Dynamics
سال: 1997
ISSN: 1058-8388,1097-0177
DOI: 10.1002/(sici)1097-0177(199706)209:2<233::aid-aja9>3.0.co;2-j